Other known proteins that bind DNA determine which genes will be expressed and in what quantity. Generally, a chromosome consists of one linear DNA molecule complexed with numerous proteins that are responsible for the organization of DNA into conformations suitable for gene replication and transcription. Chromosomes store genetic information for living organisms and are essential for eukaryotic cell differentiation and function. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. Novel polypeptides and antibodies that bind to these polypeptides are provided. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides.

The present invention relates to novel proteins. 13, 2001) on four identical compact discs (CD-R), labeled “COPY 1,” “COPY 2,” “COPY 3,” and “CRF.” The Sequence Listing complies with Annex C of the Administrative Instructions, and may be viewed, for example, on an IBM-PC machine running the MS-Windows operating system by using the V viewer software, version 2000 (see World Wide Web URL: ). The Sequence Listing is provided as an electronic file (PTZ12PCT_seqList.txt, 592,062 bytes in size, created on Jan. The Sequence Listing forms a part of this description pursuant to Rule 5.2 and Administrative Instructions Sections 801 to 806, and is hereby incorporated in its entirety. This application refers to a “Sequence Listing” that is provided only on electronic media in computer readable form pursuant to Administrative Instructions Section 801(a)(i).

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